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KMID : 0613820090190070983
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Journal of Life Science
2009 Volume.19 No. 7 p.983 ~ p.993
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Effects of Monascus-Fermented Korean Red Ginseng Powder on the Contents of Serum Lipid and Tissue Lipid Peroxidation in Alcohol Feeding Rats
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Cha Jae-Young
Ahn Hee-Young
Eom Kyung-Eun
Park Bo-Kyung
Jun Bang-Sil
Park Jin-Chul
Lee Chi-Hyeong
Cho Young-Su
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Abstract
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The effects of Monascus-fermented Korean red ginseng (MFRG) on the contents of serum lipids and tissues lipid peroxidation was investigated in alcohol feeding rats (AC group). Serum contents of total lipid and free fatty acid in alcohol feeding rats were significantly increased, but these increases tended to decrease in the AMFRG group. Serum triglyceride content was also significantly decreased in the AMFRG group compared to other groups. Serum content of total-cholesterol was significantly increased in AC group compared to normal control (NC) group, whereas there was no significant difference between the AC and AMFRG groups. Content of HDL-cholesterol in serum was slightly increased in the AC group compared to the NC group, but this increase in the AC group was more significantly increased in the AMFRG group. At the same time, atherogenic index (AI) was also significantly decreased in the AMFRG group compared to the AC group. Contents of thiobarbituric acid reactive substances (TBARS) in the liver, heart, spleen and testes were significantly increased in the AC group compared to the NC group, but these increases were significantly less in the AMFRG group. Contents of liver nonheme ion was increased in the AC group and was significantly decreased in the AMFRG group, which suggested that lipid peroxidation contents are inversely correlated with liver nonheme ion content. Hepatic glutathione concentration was significantly decreased in the AC group, but this content was significantly increased in the AMFRG group and it showed the antioxidant abilities of glutathione. These results suggested that Monascus-fermented Korea red ginseng has anti-atherogenic index (AI) effects as well as antioxidative activities through reduced tissue oxidative stress in alcohol feeding rats.
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KEYWORD
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Korean red ginseng, monascus-fermented Korean red ginseng (MFRG), atherogenic index (AI), TBARS, antioxidation
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